NASENI Headquarters Functions through its directorates structure. The staffs are made up of well qualified and professional staffs from different fields of endeavours. The Departments are as listed below.

- DG's Office

• Legal Unit
• Audit Unit
• Health and Safety Unit

- Engineering Infrastructure Department (EID)

- Science Infrastructure Department (SID)

- Technology Business Development Department (TBD)

- Adminstration and Human Resources (AHR)

- Finance and Accounts (F&A)

- Planning & Policy Analysis (PPA)